Acetone → HCID 68293504, compound

Participants

Reaction Conditions

Reaction Steps

Under inert gas, 28 g of C-(4-bromophenyl)-N-(2,4-dimethoxybenzyl)methanesulfonamide were initially charged in 250 ml of THF, and then, at a temperature of −78° C., 93 ml of a 1.6 N methyllithium solution in hexane were added dropwise and the mixture was left to stir while cooling with ice for 5 minutes. Subsequently, the reaction solution was cooled again to −78° C. and 20 ml of acetone were added. The mixture was allowed to come to room temperature and stirred for 30 minutes. The reaction solution was admixed with 13 ml of trifluoroacetic acid and 500 ml of ethyl acetate, and washed with 300 ml of a saturated aqueous sodium hydrogencarbonate solution and 300 ml of a saturated aqueous sodium chloride solution, and the organic phase was dried over Na2SO4 and concentrated by rotary evaporation. The residue was used in the next reaction without further purification.

Provenance & Evidence