Toluene → HCID 68293493, compound

Participants

Reaction Steps

A solution of N-(2,4-dimethoxybenzyl)-1-(4-bromophenyl)-2-hydroxy-2-methylpropane-1-sulfonamide from the above reaction in 150 ml of dichloromethane was admixed with 50 ml of trifluoroacetic acid and stirred at room temperature for 17 hours. The starting solution was coevaporated twice with 100 ml of toluene and the crude product was purified using a Flashmaster with an n-heptane/ethyl acetate gradient by means of normal phase chromotography. The product-containing fractions were combined and concentrated by rotary evaporation. This gave the product (16 g) with a molecular weight of 308.2 g/mol (C10H14BrNO3S).

Provenance & Evidence