Hydrochloric Acid → HCID 178431647, compound

Participants

Reaction Steps

A solution of 4-{4-[(R)-2-(2-carbamoylhexahydro-2,5-methanopentalen-3a-ylamino)-6,6-dimethyl-4,4-dioxo-5,6-dihydro-4H-4lambda*6*-[1,4,3]oxathiazin-5-yl]-phenyl}-3,6-dihydro-2H-pyridine-1-carboxylic acid butyl ester (100 mg) in methanol (10 mL) was admixed with palladium on carbon (10%, 100 mg) and the mixture was stirred in a hydrogen atmosphere for 1.5 h. The mixture was filtered and concentrated. The residue was dissolved in 5 mL of dichloromethane, and 1 mL of trifluoroacetic acid was added. After stirring at room temperature for 1 h, the solvent was removed under reduced pressure and TFA ester formed was cleaved by treatment with 1 N HCl. Extraction with ethyl acetate gave the crude product, which was used without further purification.

Provenance & Evidence