Phosphorus oxychloride → 6-Bromo-4-chlorothieno[2,3-d]pyrimidine

Participants

Role	Name	HCID	Charge
Reactant	Phosphorus oxychloride	HCID 24813	—
Reactant	Sodium Bicarbonate	HCID 516892	—
Reactant	HCID 178518066	HCID 178518066	—
Product	6-Bromo-4-chlorothieno[2,3-d]pyrimidine	HCID 12225261	83%

Reaction Conditions

Temperature	80 °C

Reaction Steps

To 6-bromothieno[2,3-d]pyrimidin-4-ol (3.0 g, 19.7 mmol) was added phosphorus oxychloride (5 mL). After heating to 80° C. for 1.5 hours, the reaction mixture was poured into saturated NaHCO3 and ice. The solid was filtered, washed with water and dried to provide the product (4.06 g, 83%) as brown solid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08648087B2
Source dataset	uspto-grants-2014_02
ORD ID	ord-7f3e5b497c8541b392a0a31a53cb64bf
Source note	uspto-grants-2014_02