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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 240577Generated: October 26, 2026

5-(2-Methyl-4-nitrophenoxy)benzo[d]oxazole → 4-(Benzo[d]oxazol-5-yloxy)-3-methylbenzenamine

https://huagongshe.com/reaction/240577

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-(2-Methyl-4-nitrophenoxy)benzo[d]oxazoleHCID 66936930—
CatalystPalladiumHCID 23938—
SolventEthanolHCID 702—
Product4-(Benzo[d]oxazol-5-yloxy)-3-methylbenzenamineHCID 6693728855.1%

Reaction Steps

To a solution of 5-(2-methyl-4-nitrophenoxy)benzo[d]oxazole (1.65 g, 6.12 mmol) in ethanol was added Pd/C (0.130 g, 0.122 mmol). After stirring under hydrogen atmosphere for 16 hours, the mixture was filtered and the filtrate was concentrated to provide the product (0.81 g, 55%) as yellow oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08648087B2
Source datasetuspto-grants-2014_02
ORD IDord-9c231314464c4c82a9eae3012e9cf287
Source noteuspto-grants-2014_02