HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloroquinazolin-6-yl acetate → 4-Chloroquinazolin-6-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloroquinazolin-6-yl acetate | HCID 18967624 | — |
| Solvent | Ammonia | HCID 222 | — |
| Product | 4-Chloroquinazolin-6-ol | HCID 23160273 | 80.2% |
Reaction Steps
A mixture of 4-chloroquinazolin-6-yl acetate (10.0 g, 44.9 mmol) and ammonia (200 mL of 7N solution in methanol) were stirred together for 1 hour. The reaction mixture was concentrated to about 3 mL and triturated with diethyl ether to provide the product (6.50 g, 80%) as tan solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08648087B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-71b573d3a15748dea2d4885ed9dff91a |
| Source note | uspto-grants-2014_02 |