Sulfamic acid 1-ethyl-cyclopropyl ester → 2-[2-Ethyl-1-(1-ethyl-cyclopropoxysulfonylaminocarbonyl)-cyclopropylcarbamoyl]-4-(6-methoxy-isoquinolin-1-yloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester

Participants

Reaction Steps

2-[2-Ethyl-1-(1-ethyl-cyclopropoxysulfonylaminocarbonyl)-cyclopropylcarbamoyl]-4-(6-methoxy-isoquinolin-1-yloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester was prepared according to the method presented in Example 27. Treatment of 2-(1-carboxy-2-ethyl-cyclopropylcarbamoyl)-4-(6-methoxy-isoquinolin-1-yloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester (0.70 mmol) occurred under the same conditions, adjusted for scale with the exception of utilizing sulfamic acid 1-ethyl-cyclopropyl ester to afford the desired acylsulfamate (230 mg, 51%): LCMS found 647.1 [M+H]+.

Provenance & Evidence