HCID 86677188, compound → HCID 86677190, compound

Participants

Reaction Steps

A mixture of [4-[tert-butyl(dimethyl)silyl]-3,5,6-trifluoro-2-pyridyl]-(4,6-dichloropyrimidin-5-yl)methanol (1.21 g, 2.85 mmol) and Manganese (IV) oxide (3.72 g, 42.78 mmol) in DCM (53 mL) was stirred at ambient temperature for 5 days. After this time, further Manganese (IV) oxide (992 mg, 11.4 mmol) was added and stirred at ambient for 2 hours. The reaction mixture was filtered through a celite cartridge, washing through with DCM, and the filtrate concentrated in vacuo to leave the sub title product as a white solid (908 mg, 74.8% Yield). H1 NMR (400 MHz, DMSO) δ 9.15 (1H, s), 0.94 (9H, s) and 0.45 (6H, s).

Provenance & Evidence