4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylaniline → HCID 66937217, compound

HRID 240590Notes

Reaction equation

HRID 240590 reaction equation
[Si:1]([O:18][CH2:19][C:20]([NH:24][C:25](=S)[NH:26][C:27]1[CH:32]=[CH:31][C:30](/[N:33]=[CH:34]/[N:35](C)C)=[C:29]([C:38]#N)[CH:28]=1)([CH3:23])[CH2:21][OH:22])([C:14]([CH3:17])([CH3:16])[CH3:15])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N:41]1[CH:42]=[N:43][N:44]2[CH:49]=[CH:48][C:47]([O:50][C:51]3[CH:56]=[CH:55][C:54]([NH2:57])=[CH:53][C:52]=3[CH3:58])=[CH:46][C:45]=12>>[N:41]1[CH:42]=[N:43][N:44]2[CH:49]=[CH:48][C:47]([O:50][C:51]3[CH:56]=[CH:55][C:54]([NH:57][C:38]4[C:29]5[C:30](=[CH:31][CH:32]=[C:27]([NH:26][C:25]6[O:22][CH2:21][C:20]([CH2:19][O:18][Si:1]([C:14]([CH3:17])([CH3:16])[CH3:15])([C:8]7[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=7)[C:2]7[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=7)([CH3:23])[N:24]=6)[CH:28]=5)[N:33]=[CH:34][N:35]=4)=[CH:53][C:52]=3[CH3:58])=[CH:46][C:45]=12

Participants

3

Reactant 2

HCID 669370134-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylanilineHCID 178484247HCID 178484247, compound

Product 1

HCID 66937217HCID 66937217, compound

Procedure

Prepared according to the method of Example 1, using (E)-N′-(4-(3-(1-(tert-butyldiphenylsilyloxy)-3-hydroxy-2-methylpropan-2-yl)thioureido)-2-cyanophenyl)-N,N-dimethylformimidamide in place of 1-(3-cyano-4-((dimethylamino)methyleneamino)phenyl)-3-(1-hydroxy-2-methylpropan-2-yl)thiourea and 4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylbenzenamine in place of 4-(imidazo[1,2-a]pyridin-7-yloxy)-3-methylaniline.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-2c6b0717344a4598861d1bbe5635fdb1
Source dataset
uspto-grants-2014_02
Patent number
US08648087B2

Reaction notes

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