関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Azide | HCID 33557 | — |
| 反応物 | (R)-ethyl 4-bromo-2-methyl-2-(methylsulfonyl)butanoate | HCID 86670635 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | ethyl (2R)-4-azido-2-methyl-2-(methylsulfonyl)butanoate | HCID 86710224 | — |
反応手順
To a solution of ethyl (2R)-4-bromo-2-methyl-2-(methylsulfonyl)butanoate (4.5 g, 15.7 mmol, 1 eq) in DMSO (5 mL) was added sodium azide (1.02 g, 15.7 mmol, 1 eq). The mixture was heated at 80° C. for 3 h. The mixture was then diluted with EtOAc and washed with water. The organic layer was dried (MgSO4), filtered and concentrated to give ethyl (2R)-4-azido-2-methyl-2-(methylsulfonyl)butanoate which was used without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08809333B2 |
|---|
| 出典データセット | uspto-grants-2014_08 |
|---|
| ORD ID | ord-8477307018c54c14bb9b7785630d73cd |
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| 出典メモ | uspto-grants-2014_08 |
|---|
