HCID 86710231, compound → HCID 86710232, compound

Participants

Reaction Steps

A solution of ethyl (2R)-4-[4-(cyclopent-1-en-1-yl)-1H-pyrazol-1-yl]-2-methyl-2-(methylsulfonyl)butanoate (250 mg, 0.734 mmol, 1 eq) in MeOH (30 mL) was subjected to hydrogenation conditions (10% Pd/C catcart, 10 bar H2 pressure) on a Thales nano H-cube. The mixture was concentrated to give ethyl (2R)-4-(4-cyclopentyl-1H-pyrazol-1-yl)-2-methyl-2-(methylsulfonyl)butanoate (100 mg, 40% yield) which was used without further purification. LC-MS M+H+343.4.

Provenance & Evidence