Hydrochloric Acid → HCID 70817619, compound

Participants

Reaction Steps

To a solution of ethyl (2R)-4-(4-cyclopentyl-1H-pyrazol-1-yl)-2-methyl-2-(methylsulfonyl)butanoate (100 mg, 0.292 mmol) in dioxane (3 mL) was added a 2M LiOH solution (0.0876 mL, 1.75 mmol, 6 eq). The reaction was allowed to stir overnight at RT. The mixture was then acidified with 1M HCl. The aqueous phase was then extracted with EtOAc, dried (MgSO4), filtered, and concentrated in vacuo to give (2R)-4-(4-cyclopentyl-1H-pyrazol-1-yl)-2-methyl-2-(methylsulfonyl)butanoic acid (92 mg, 100% yield) which was used without further purification. LC-MS M+H+315.1.

Provenance & Evidence