Hydrochloric Acid → HCID 70817564, compound

Participants

Reaction Steps

To a solution of (2R)-2-methyl-4-(4-methyl-1H-pyrazol-1-yl)-2-(methylsulfonyl)butanoate (182 mg 0.455 mmol, 1 eq) in 2:2:1 THF-MeOH-water (6 mL) was added 0.1 M aq. LiOH and the reaction mixture was allowed to stir overnight at RT. The reaction mixture was concentrated under reduced pressure (to remove organics) to provide an aqueous solution, which was diluted with water (5 mL) and acidified to pH=2 with 1 M HCl. Upon acidification, a white precipitate formed, which was filtered, washed with water, and dried under reduced pressure to give (2R)-2-methyl-4-(4-methyl-1H-pyrazol-1-yl)-2-(methylsulfonyl)butanoic acid. LC-MS M+H+261.1.

Provenance & Evidence