Hydrochloric Acid → HCID 66558213, compound

Participants

Reaction Steps

To a solution of (2R)-2-methyl-2-(methylsulfonyl)-4-(4-phenyl-1H-pyrazol-1-yl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide (0.685 g, 1.62 mmol, 1 eq) in THF (20 mL) was added HCl (4M aq. sol.) and the reaction was allowed to stir at RT overnight. The reaction mixture was concentrated and azeotroped with MeOH to remove water to give (2R)—N-hydroxy-2-methyl-2-(methylsulfonyl)-4-(4-phenyl-1H-pyrazol-1-yl)butanamide (497 mg, 91% yield) as a white solid. 1H NMR (400 MHz, DMSO-d6) δ 10.85-10.73 (m, 1H), 10.30-10.18 (m, 1H), 8.19 (s, 1H), 7.86 (s, 1H), 7.60-7.50 (m, 2H), 7.32 (t, J=7.7 Hz, 2H), 7.15 (s, 1H), 4.27-4.14 (m, 1H), 4.10-3.95 (m, 1H), 3.04 (s, 3H), 2.79-2.63 (m, 1H), 2.32-2.18 (m, 1H), 1.46 (s, 3H). LC-MS M+H+338.0.

Provenance & Evidence