Cesium carbonate → HCID 86710242, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-(1H-pyrazol-4-yl)pyrazine (0.157 g, 1.07 mmol) in acetonitrile (10 mL) was added cesium carbonate (0.873 g, 2.78 mmol, 2.5 eq), sodium sulfate (0.032 g, 0.214 mmol, 0.2 eq) and (R)-ethyl 4-bromo-2-methyl-2-(methylsulfonyl)butanoate (0.4 g 1.39 mmol, 1.3 eq). The mixture was heated at 50° C. overnight. The reaction mixture was filtered over a pad of diatomateous earth. The filtrate was evaporated in vacuo. The crude product was purified by flash chromatography on silica gel eluting with 40-100% ethyl acetate/heptane to give ethyl (2R)-2-methyl-2-(methylsulfonyl)-4-[4-(pyrazin-2-yl)-1H-pyrazol-1-yl]butanoate (0.320 g, 1.39 mmol, 65% yield). LC-MS M+H+353.2.

Provenance & Evidence