Hydrochloric Acid → HCID 66558215, compound

Participants

Reaction Steps

To a solution of (2R)-2-methyl-2-(methylsulfonyl)-4-[4-(pyrazin-2-yl)-1H-pyrazol-1-yl]-N-(tetrahydro-2H-pyran-2-yloxy)butanamide (0.182 g, 0.430 mmol) in EtOH (8 mL) was added 1M HCl (15 mL). The reaction mixture was allowed to stir at RT overnight. The reaction mixture was concentrated, and azeotroped with methanol to remove water to give (2R)—N-hydroxy-2-methyl-2-(methylsulfonyl)-4-[4-(pyrazin-2-yl)-1H-pyrazol-1-yl]butanamide (142 mg, 97% yield) as an off-white solid. 1H NMR (400 MHz, DMSO-d6) δ 1.49 (s, 3H) 2.21-2.33 (m, 1H) 2.68-2.80 (m, 1H) 3.06 (s, 3H) 4.05-4.15 (m, 1H) 4.22-4.32 (m, 1H) 8.12 (s, 1H) 8.40 (d, J=2.54 Hz, 1H) 8.50 (s, 1H) 8.54 (dd, J=2.54, 1.56 Hz, 1H) 8.96 (d, J=1.56 Hz, 1H) 10.93 (br. s., 1H) 11.14 (s, 1H) LC-MS M+H+340.1.

Provenance & Evidence