Hydrochloric Acid → HCID 66558216, compound

Participants

Reaction Steps

To a solution of (2R)-2-methyl-2-(methylsulfonyl)-4-[4-(quinoxalin-2-yl)-1H-pyrazol-1-yl]-N-(tetrahydro-2H-pyran-2-yloxy)butanamide (0.685 g, 1.62 mmol, 1 eq) in EtOH (8 mL) was added 1M HCl (4 mL). The reaction mixture was allowed to stir at RT overnight. The reaction mixture was concentrated and azeotroped with MeOH to remove water to give (2R)—N-hydroxy-2-methyl-2-(methylsulfonyl)-4-[4-(quinoxalin-2-yl)-1H-pyrazol-1-yl]butanamide (38 mg, 86% yield) as a light yellow solid. 1H NMR (400 MHz, DMSO-d6) δ 1.51 (s, 3H) 2.26-2.37 (m, 1H) 2.72-2.85 (m, 1H) 3.07 (s, 3H) 4.10-4.20 (m, 1H) 4.27-4.38 (m, 1H) 7.73 (s, 1H) 7.80 (s, 1H) 7.98 (d, J=8.39 Hz, 1H) 8.02 (d, J=0.78 Hz, 1H) 8.31 (s, 1H) 8.72 (s, 1H) 9.30 (s, 1H) 10.23 (s, 1H) 11.01 (br. s., 1H). LC-MS M+H+390.1.

Provenance & Evidence