反应详情

To a solution of (S)-tert-butyl 3-(5-fluoro-2-nitrophenoxy)piperidine-1-carboxylate (6.41 g) in MeOH (70.0 ml) was added palladium on charcoal (600.0 mg), the mixture hydrogenated at room temperature and 50 psi. The catalyst was filtered off and the filtrate was concentrated under reduced pressure. The residue was purified by silica chromatography to give the desired product.

1. customhydrogenated at room temperature
2. filtrationThe catalyst was filtered off
3. concentrationthe filtrate was concentrated under reduced pressure
4. customThe residue was purified by silica chromatography