Hydrochloric Acid → (2R)-4-[4-(1,3-benzoxazol-2-yl)-1H-pyrazol-1-yl]-2-methyl-2-(methylsulfonyl)butanoic acid

Participants

Reaction Steps

To a solution of ethyl (2R)-4-[4-(1,3-benzoxazol-2-yl)-1H-pyrazol-1-yl]-2-methyl-2-(methylsulfonyl)butanoate (0.482 g, 1.23 mmol) in THF/H2O (20 mL:10 mL) was added lithium hydroxide (0.295 g, 12.3 mmol, 10 eq). The mixture was allowed to stir at RT overnight. The mixture was acidified with 1M HCl and extracted with ethyl acetate. The organic layers were combined, dried over sodium sulfate, filtered, and concentrated to give (2R)-4-[4-(1,3-benzoxazol-2-yl)-1H-pyrazol-1-yl]-2-methyl-2-(methylsulfonyl)butanoic acid (0.420 g, 94% yield) as a white solid. LC-MS M+H+364.1.

Provenance & Evidence