Hydrochloric Acid → HCID 66558300, compound

Participants

Reaction Steps

To a solution of (2R)-4-{4-[(3-cyanophenyl)ethynyl]-1H-pyrazol-1-yl}-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide (0.209 g, 0.444 mmol) in EtOH (40 mL) was added 1M HCl (20 mL). The reaction was allowed to stir at room temperature overnight. The reaction mixture was concentrated, taken back up in MeOH, and concentrated again to give (2R)-4-{4-[(3-cyanophenyl)ethynyl]-1H-pyrazol-1-yl}-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide (160 mg, 93% yield) as a white solid.

Provenance & Evidence