Hydrochloric Acid → HCID 70817556, compound

Participants

Reaction Steps

To a solution of the mixture of ethyl (2R)-2-methyl-4-(5-methyl-4-phenyl-1H-1,2,3-triazol-1-yl)-2-(methylsulfonyl)butanoate and ethyl (2R)-2-methyl-4-(4-methyl-5-phenyl-1H-1,2,3-triazol-1-yl)-2-(methylsulfonyl)butanoate (150 mg, 0.41 mmol, 1 eq) in THF (5 mL) and water (1 mL) was added LiOH (0.41 mmol, 1 eq) and the reaction mixture was allowed to stir at RT overnight. The reaction mixture was acidified with 1M HCl and extracted with CH2Cl2. The organic layer was dried (MgSO4), filtered and concentrated and the crude product was used in the next step without further purification.

Provenance & Evidence