Aluminium lithium hydride → HCID 58413055, compound

Participants

Reaction Steps

Lithium aluminium hydride (540.0 mg) added to a cooled (0-4° C.) solution of (2S,4S)-1-tert butyl 2-methyl 4-(2-amino-5-fluorophenoxy)pyrrolidine-1,2-dicarboxylate (3.36 g) in THF (30.0 ml). The reaction mixture was stirred at this temperature for 4 h. After this time the mixture was quenched with water (0.54 ml), NaOH (2M; 0.54 ml) and water (3×0.54 ml). The mixture was stirred for 1.5 h, then diluted with EtOAc and MgSO4 was added. The suspension was filtered through celite and the filtrate evaporated. The residue was purified by chromatography.

Provenance & Evidence