HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → tert-Butyl 4-(4-chlorophenyl)-4-cyanopiperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Piperidinocarbonitrile | HCID 73736 | — |
| Reactant | 4-Chlorobenzyl cyanide | HCID 241582 | — |
| Reactant | N-BOC-N,N-Bis(2-chloroethyl)amine | HCID 11230235 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | tert-Butyl 4-(4-chlorophenyl)-4-cyanopiperidine-1-carboxylate | HCID 49760270 | — |
Reaction Steps
4-Chlorophenylacetonitrile was reacted with three equivalents of sodium hydride and one equivalent of N-tert-butyloxycarbonyl-bis-(2-chloroethyl)amine in DMF, initially at room temperature and then at 60° C. to give, after work up, the N-protected piperidine nitrile title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08809336B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-9a9191f4391d451583e6cc03ac2fde42 |
| Source note | uspto-grants-2014_08 |