p-Toluenesulfonic acid → Methyl 4-(4-fluoro-2-hydroxyphenylamino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylate

関与物質

役割	名称	HCID	仕込み量
反応物	p-Toluenesulfonic acid	HCID 6101	—
反応物	Ammonium Hydroxide	HCID 14923	—
反応物	2-Amino-5-fluorophenol	HCID 185763	—
反応物	Methyl 4-chloro-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate	HCID 2759834	—
溶媒	1,4-Dioxane	HCID 31275	—
生成物	Methyl 4-(4-fluoro-2-hydroxyphenylamino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylate	HCID 58413076	—

反応条件

温度	120 °C

反応手順

4-Chloro-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester (2.43 g), 2-amino-5-fluorophenol (2.43 g) and p-toluenesulfonic acid (190.0 mg) were dissolved in dioxane (50.0 ml) and heated at 120° C. for 4 h under nitrogen. The reaction mixture was allowed to cool and treated with 3M NH4OH. The resultant suspension was filtered, the solid was washed with ether and dried in vacuo at 60° C. over P2O5.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US08648068B2
出典データセット	uspto-grants-2014_02
ORD ID	ord-cf324c23c5ed405093e176a4ce654e97
出典メモ	uspto-grants-2014_02