HCID 58413223, compound → HCID 58413003, compound

HRID 240599Notes

Reaction equation

HRID 240599 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([N+:14]([O-])=O)=[C:6]([CH:13]=1)[O:7][C@@H:8]1[CH2:12][CH2:11][O:10][CH2:9]1>CO.[Ni]>[F:1][C:2]1[CH:3]=[CH:4][C:5]([NH2:14])=[C:6]([O:7][C@@H:8]2[CH2:12][CH2:11][O:10][CH2:9]2)[CH:13]=1

Participants

4

Reactant 1

HCID 58413223HCID 58413223, compound

Product 1

HCID 58413003HCID 58413003, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

To a solution of (R)-3-(5-fluoro-2-nitrophenoxy)tetrahydrofuran (1.8 g) in MeOH (60.0 ml) was added Ra/Ni (200.0 mg), the mixture hydrogenated at room temperature. The catalyst was filtered off and the filtrate was concentrated.

Workup

  1. customhydrogenated at room temperature
  2. filtrationThe catalyst was filtered off
  3. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-e3a4a21eea60440e913ef549c8f7f5e3
Source dataset
uspto-grants-2014_02
Patent number
US08648068B2

Reaction notes

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