Hydrochloric Acid → Amiselimod(MT-1303) hydrochloride

Participants

Reaction Conditions

Reaction Steps

Compound 1-2 (640 mg) was dissolved in ethanol (15 ml), concentrated hydrochloric acid (3 ml) was added, and the mixture was stirred at 80° C. for 2 hr. The reaction mixture was concentrated, and the residue was washed with diethyl ether to give the object product (492 mg) as white powder.

Provenance & Evidence