Hydrochloric Acid → HCID 67417807, compound

Participants

Reaction Steps

Compound 5-1 (255 mg) was dissolved in ethanol (2 ml), p-toluenesulfonic acid (19 mg) was added, and the mixture was stirred at room temperature for 4 hr. To the reaction mixture was added saturated aqueous sodium hydrogencarbonate, and the mixture was extracted with ethyl acetate, washed with saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure and the residue was purified by silica gel column chromatography (hexane:ethyl acetate=4:1) to give an oil. To the oil was added dioxane containing hydrogen chloride (4 mol/l), and the mixture was stirred at room temperature for 3 hr. The precipitate was collected by filtration and dried to give the object product (45 mg) as a white powder.

Provenance & Evidence