反应详情

A solution of 2-fluoro-4-iodo-benzyl bromide (Intermediate 1, 2.56 g, 8.15 mmol) in ethanol (55 mL and water (10 mL) was treated with sodium cyanide (2.15 g, 43.86 mmol) and refluxed for 0.5 h. The volatiles were distilled off in vacuo and the residue was diluted with water and extracted with diethyl ether (×2). The combined organic extract was washed with water (×1) and brine (×1), dried over anhydrous magnesium sulfate, filtered and evaporated in vacuo to afford the title compound as a pale yellow solid (2.05 g, 96%).

1. temperaturerefluxed for 0.5 h
2. distillationThe volatiles were distilled off in vacuo
3. additionthe residue was diluted with water
4. extractionextracted with diethyl ether (×2)
5. extractionThe combined organic extract
6. washwas washed with water (×1) and brine (×1)
7. dry with materialdried over anhydrous magnesium sulfate
8. filtrationfiltered
9. customevaporated in vacuo