Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Succinic Acid | HCID 1110 | — |
| Reactant | HCID 178457291 | HCID 178457291 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 178457292 | HCID 178457292 | — |
Reaction Steps
1 g of 3-(3-{2-[(E)-3,5-Diamino-6-chloro-pyrazine-2-carbonylimino]-1,3,8-triaza-spiro[4.5]decane-8-carbonyl}-benzenesulfonylamino)-propionic acid dipropylcarbamoylmethyl ester (may be prepared as in Preparation 1) and 0.18 g succinic acid were dissolved in 7.97 g methanol in a glass vial at 50° C. The solution was cooled to 0° C. and then stirred at that temperature for 24 hours. Afterwards, crystals were collected by filtration and dried at 60° C. and 1 mbar for 3 hours. Off-white to yellowish crystals of form C were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08809340B2 |
|---|
| Source dataset | uspto-grants-2014_08 |
|---|
| ORD ID | ord-431737c4db604c6aba6d5d8d13667249 |
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| Source note | uspto-grants-2014_08 |
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