HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 58413175, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 1-Methyl-3-aminopyrazole | HCID 137254 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 58413177 | HCID 58413177 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 58413175 | HCID 58413175 | — |
Reaction Steps
HATU was added into a solution of 4-[2-((S)-1-tert-Butoxycarbonyl-piperidin-3-yloxy)-4-fluoro-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid (100 mg) and DIPEA in anhydrous DMF (2 ml) at 0° C. The reaction was stirred for 0.5 h when 1-methyl-1H-pyrazol-3-amine (100 μl) was added and the reaction allowed to warm to room temperature and stirred for 2 h. The DMF was removed by co-evaporation from toluene and the residue was purified by chromatography to give the intended product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08648068B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-2c7c1bb3e3c1478dbd62017dc4d3bc39 |
| Source note | uspto-grants-2014_02 |