HCID 86652649, compound → HCID 86652648, compound

HRID 2406198Notes

Reaction equation

HRID 2406198 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH:11][C:12]([NH:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])=[S:13])=[C:6]([CH:10]=1)[C:7](O)=[O:8]>C(OC(=O)C)(=O)C>[Br:1][C:2]1[CH:10]=[C:6]2[C:5](=[CH:4][CH:3]=1)[NH:11][C:12](=[S:13])[N:14]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[C:7]2=[O:8]

Participants

3

Reactant 1

HCID 86652649HCID 86652649, compound

Product 1

HCID 86652648HCID 86652648, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent

Conditions

Temperature
60 °C

Procedure

Compound 2a (12.3 g, 35.5 mmol) was dissolved in 150 mL of acetic anhydride and stirred at 60° C. for 4 hour. The mixture was slowly cooled to 4° C. under crystallization and the white crystals formed were filtered off, washed with cold acetic anhydride and dried under vacuum, to give 3a (10.8 g, 32.8 mmol, 93%). mp: 214.0° C.

Workup

  1. temperatureThe mixture was slowly cooled to 4° C. under crystallization
  2. customthe white crystals formed
  3. filtrationwere filtered off
  4. washwashed with cold acetic anhydride
  5. customdried under vacuum

Sources & evidence

ORD record
ord-f96874cc1d2f4fe2b33450fe60a15b4b
Source dataset
uspto-grants-2014_08
Patent number
US08809355B2

Reaction notes

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