反应详情

A solution of 2-fluoro-4-iodo-phenyl acetonitrile (Intermediate 2, 2.05 g, 7.83 mmol) in ethanol (50 mL and water (15 mL) was treated with potassium hydroxide (3.4 g, 60.7 mmol) and refluxed for 4 h. The volatiles were distilled off in vacuo and the residue was diluted with water and poured into cold, dilute hydrochloric acid and the precipitated solid was filtered. The solid was dissolved in diethyl ether, and the organic solution was dried over anhydrous magnesium sulfate, filtered and evaporated in vacuo to afford the title compound a pale yellow solid (1.75 g, 79%).

1. temperaturerefluxed for 4 h
2. distillationThe volatiles were distilled off in vacuo
3. additionthe residue was diluted with water
4. additionpoured into cold, dilute hydrochloric acid
5. filtrationthe precipitated solid was filtered
6. dissolutionThe solid was dissolved in diethyl ether
7. dry with materialthe organic solution was dried over anhydrous magnesium sulfate
8. filtrationfiltered
9. customevaporated in vacuo