1,2-Dichloroethane → HCID 58413108, compound

Participants

Reaction Steps

EDC (74 mg) added to a mixture of the 4-[2-((S)-1-tert-butoxycarbonyl-piperidin-3-yloxy)-4-trifluoromethyl-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid (177 mg) and N-hydroxysuccinimide (55 mg) in DMF (4 ml). The reaction mixture was stirred at room temperature overnight. The reaction was diluted with EtOAc and washed with water and brine. The organics were passed through a hydrophobic frit and the solvent was evaporated. The residue was dissolved in DMF (2 ml) and ammonia in methanol (2 ml) was added. The reaction was stirred for 1 h. Further ammonia in methanol (2 ml) was added and the reaction was stirred again. After 30 min the reaction was diluted with EtOAc and washed with water and brine.

Provenance & Evidence