1,10-Phenanthroline → HCID 67017224, compound

Participants

Reaction Conditions

Reaction Steps

N,N-Dimethylformamide (20 mL) was added to a mixture of 4-iodotoluene (3.0 g, 13.8 mmol), ethyl carbonate (1.72 g, 16.5 mmol), 1,10-phenanthroline (0.50 g, 2.76 mmol), copper(I) iodine (0.131 g, 0.69 mmol) and cesium carbonate (6.3 g, 19.3 mmol) and the mixture was heated under N2 at 80° C. for 18 h. The crude mixture was concentrated in vacuo and purified by chromatography on a silica gel column. Elution with n-heptane/EtOAc (4:1) as eluent afforded 10a as a white solid (2.22 g, 83%). mp. 35° C.,

Provenance & Evidence