HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 240623Generated: November 2, 2026
Ammonia → 4-[4-Chloro-2-((S)-piperidin-3-yloxy)-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid amide
https://huagongshe.com/reaction/240623
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 4-{4-Chloro-2-[(S)-1-(2,2,2-trifluoro-acetyl)-piperidin-3-yloxy]-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester | HCID 58413216 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-[4-Chloro-2-((S)-piperidin-3-yloxy)-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid amide | HCID 58413144 | — |
Reaction Steps
4-{4-Chloro-2-[(S)-1-(2,2,2-trifluoro-acetyl)-piperidin-3-yloxy]-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester (150 mg) and ammonia in methanol (7M; 5 ml) were combined and heated at 100° C. in sealed tube. The reaction heated under these conditions for 48 h. The residue was purified by chromatography tho give the inteded product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08648068B2 |
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| Source dataset | uspto-grants-2014_02 |
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| ORD ID | ord-345aec5582ec4f23bfbb98a83d6ad2ef |
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| Source note | uspto-grants-2014_02 |
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