HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 4-chloro-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate → 4-{4-Methyl-2-[(S)-1-(2,2,2-trifluoro-acetyl)-piperidin-3-yloxy]-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 4-chloro-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate | HCID 2759834 | — |
| Reactant | (S)-1-(3-(2-amino-5-methylphenoxy)piperidin-1-yl)-2,2,2-trifluoroethanone | HCID 58413119 | — |
| Product | 4-{4-Methyl-2-[(S)-1-(2,2,2-trifluoro-acetyl)-piperidin-3-yloxy]-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester | HCID 58413113 | — |
Reaction Steps
Prepared analogously to example 65.1. from 4-chloro-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester and (S)-1-(3-(2-amino-5-methylphenoxy)piperidin-1-yl)-2,2,2-trifluoroethanone
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08648068B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-44f9704243674f88be0f2959ce2d730f |
| Source note | uspto-grants-2014_02 |