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Methyl 4-chloro-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate → 4-[2-((R)-1-tert-Butoxycarbonyl-piperidin-3-yloxy)-4-fluoro-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl 4-chloro-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate | HCID 2759834 | — |
| 反応物 | (R)-tert-butyl 3-(2-amino-5-fluorophenoxy)piperidine-1-carboxylate | HCID 58413198 | — |
| 生成物 | 4-[2-((R)-1-tert-Butoxycarbonyl-piperidin-3-yloxy)-4-fluoro-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester | HCID 58413127 | — |
反応手順
Prepared analogously to example 65.1. from 4-chloro-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester and (R)-tert-butyl 3-(2-amino-5-fluorophenoxy)piperidine-1-carboxylate (Intermediate II).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08648068B2 |
| 出典データセット | uspto-grants-2014_02 |
| ORD ID | ord-c9b7a1d2dbb843129c8675301f52743d |
| 出典メモ | uspto-grants-2014_02 |