反应详情

A mixture of 4-[2-((R)-1-tert-Butoxycarbonyl-piperidin-3-yloxy)-4-fluoro-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester (1.65 g) in MeOH/THF (1:1; 20 ml) was treated with NaOH (2M; 8 ml) and heated at reflux for 10 mins. Organic solvent was removed in vacuo. HCl (2M; 8 ml) was added to pH 1 and water was added. The suspension was filtered and washed with water. The solid was suspended in EtOH and evaporated. The residue was triturated with Acetonitrile to give the desired product.

1. temperatureheated
2. temperatureat reflux for 10 mins
3. customOrganic solvent was removed in vacuo
4. additionHCl (2M; 8 ml) was added to pH 1 and water
5. additionwas added
6. filtrationThe suspension was filtered
7. washwashed with water
8. customevaporated
9. customThe residue was triturated with Acetonitrile