2,2,2-Trifluoroethyl trifluoromethanesulfonate → HCID 58413099, compound

HRID 240629Notes

Reaction equation

HRID 240629 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[C:10]3[C:17]([CH3:18])=[C:16]([C:19]([NH2:21])=[O:20])[S:15][C:11]=3[N:12]=[CH:13][N:14]=2)=[C:4]([O:22][C@@H:23]2[CH2:28][CH2:27][CH2:26][NH:25][CH2:24]2)[CH:3]=1.FC(F)(F)[CH2:31][O:32]S(C(F)(F)F)(=O)=O>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[C:10]3[C:17]([CH3:18])=[C:16]([C:19]([NH2:21])=[O:20])[S:15][C:11]=3[N:12]=[CH:13][N:14]=2)=[C:4]([O:22][C@@H:23]2[CH2:28][CH2:27][CH2:26][N:25]([CH2:10][C:9]3[N:14]=[CH:31][O:32][N:8]=3)[CH2:24]2)[CH:3]=1

Participants

3

Reactant 2

HCID 803662,2,2-Trifluoroethyl trifluoromethanesulfonateHCID 58413095HCID 58413095, compound

Product 1

HCID 58413099HCID 58413099, compound

Procedure

The following compound was prepared analogously to example 72 from 4-[4-fluoro-2-((R)-piperidin-3-yloxy)-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid amide and trifluoro-methanesulfonic acid 2,2,2-trifluoro-ethyl ester.

Sources & evidence

ORD record
ord-0518d0226dee4aff9c8964cd879d3157
Source dataset
uspto-grants-2014_02
Patent number
US08648068B2

Reaction notes

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