Dimethylformamide → HCID 58413075, compound

Participants

Reaction Steps

Acrylonitrile (20 μl) was added to a suspension of 4-[4-fluoro-2-((R)-piperidin-3-yloxy)-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid amide (60 mg) and triethylamine (42 μl), in methanol (1 ml). After 1 h DMF (0.5 ml) was added. The reaction mixture was stirred at room temperature overnight. The reaction was diluted with EtOAc and washed with water and brine. The organic phase was passed through a hydrophobic frit and evaporated. The residue was triturated with diethylether.

Provenance & Evidence