Sodium Hydroxide → HCID 58413214, compound

HRID 240632Notes

Reaction equation

[OH-].[Li+].[CH3:3][O:4][C:5]([C:7]1[S:30][C:10]2[N:11]=[CH:12][N:13]=[C:14]([NH:15][C:16]3[CH:21]=[CH:20][C:19]([F:22])=[CH:18][C:17]=3[O:23][C@H:24]3[CH2:29][CH2:28][CH2:27][O:26][CH2:25]3)[C:9]=2[C:8]=1[CH3:31])=[O:6].[OH-].[Na+]>>[CH3:3][O:4][C:5]([C:7]1[S:30][C:10]2[N:11]=[CH:12][N:13]=[C:14]([NH:15][C:16]3[CH:21]=[CH:20][C:19]([F:22])=[CH:18][C:17]=3[O:23][C@H:24]3[CH2:29][CH2:28][CH2:27][O:26][CH2:25]3)[C:9]=2[C:8]=1[CH3:31])=[O:6]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 67395680HCID 67395680, compound

Product 1

HCID 58413214HCID 58413214, compound

Procedure

Prepared analogously to example 1.2 from 4-{4-fluoro-2-[(S)-(tetrahydro-pyran-3-yl)oxy]-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester Lithiumhydroxide was replaced by NaOH (2M).

Sources & evidence

ORD record: ord-c21b8063d01149ccab4196b9f02d42d4
Source dataset: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08648068B2

Reaction notes

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