N,N-Dimethyl-1,3-propanediamine → HCID 53373920, compound

HRID 240633Notes

Reaction equation

HRID 240633 reaction equation
CO[C:3]([C:5]1[S:28][C:8]2[N:9]=[CH:10][N:11]=[C:12]([NH:13][C:14]3[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=3[O:21][C@H:22]3[CH2:27][CH2:26][CH2:25][O:24][CH2:23]3)[C:7]=2[C:6]=1[CH3:29])=[O:4].[CH3:30][N:31]([CH3:36])[CH2:32][CH2:33][CH2:34][NH2:35]>>[CH3:30][N:31]([CH3:36])[CH2:32][CH2:33][CH2:34][NH:35][C:3]([C:5]1[S:28][C:8]2[N:9]=[CH:10][N:11]=[C:12]([NH:13][C:14]3[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=3[O:21][C@H:22]3[CH2:27][CH2:26][CH2:25][O:24][CH2:23]3)[C:7]=2[C:6]=1[CH3:29])=[O:4]

Participants

3

Reactant 2

HCID 7993N,N-Dimethyl-1,3-propanediamineHCID 58413214HCID 58413214, compound

Product 1

HCID 53373920HCID 53373920, compound

Procedure

Prepared analogously to example 10.4 from 4-{4-fluoro-2-[(S)-(tetrahydro-pyran-3-yl)oxy]-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester and N,N-dimethyl-1,3-propanediamine.

Sources & evidence

ORD record
ord-1b19da14556e46599a91af69b775e344
Source dataset
uspto-grants-2014_02
Patent number
US08648068B2

Reaction notes

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