2-Fluoro-4-(methylsulphonyl)benzeneboronic acid → 5-(2-Fluoro-4-methylsulfonyl-phenyl)-1''-tert-butoxycarbonyl-dispiro[2,3-dihydrofuro[2,3-c]pyridine-2,1'-cyclobutane-3',4''-piperidine]

Beteiligte Stoffe

Reaktionsschritte

The title compound is prepared from 5-chloro-1″-tert-butoxycarbonyl-dispiro[2,3-dihydrofuro[2,3-c]pyridine-2,1′-cyclobutane-3′,4″-piperidine] and 2-fluoro-4-methylsulfonyl-phenylboronic acid following a procedure analogous to that described for Example 2; PdCl2[1,1′-bis(diphenylphosphino)-ferrocene]*CH2Cl2 complex is the preferred catalyst used. LC (method 1): tR=1.30 min; Mass spectrum (ESI+): m/z=503 [M+H]+.

Herkunft & Nachweise