2,5-Dichloropyrimidine → 1''-(5-Chloro-pyrimidin-2-yl)-5-(1-methanesulfonyl-1,2,3,6-tetrahydro-pyridin-4-yl)-dispiro[2,3-dihydrofuro[2,3-c]pyridine-2,1'-cyclobutane-3',4''-piperidine]

Participants

Reaction Steps

The title compound is prepared from 5-(1-methanesulfonyl-1,2,3,6-tetrahydro-pyridin-4-yl)-dispiro[2,3-dihydrofuro[2,3-c]pyridine-2,1′-cyclobutane-3′,4″-piperidine] (HCl salt) and 2,5-dichloro-pyrimidine following a procedure analogous to that described for Example 4. LC (method 1): tR=1.17 min; Mass spectrum (ESI+): m/z=502/504 (Cl) [M+H]+.

Provenance & Evidence