2-Chloro-5-propylpyrimidine → 5-(1-Methanesulfonyl-1,2,3,6-tetrahydro-pyridin-4-yl)-1''-(5-n-propyl-pyrimidin-2-yl)-dispiro[2,3-dihydrofuro[2,3-c]pyridine-2,1'-cyclobutane-3',4''-piperidine]

Participants

Reaction Steps

The title compound is prepared from 5-(1-methanesulfonyl-1,2,3,6-tetrahydro-pyridin-4-yl)-dispiro[2,3-dihydrofuro[2,3-c]pyridine-2,1′-cyclobutane-3′,4″-piperidine] (HCl salt) and 2-chloro-5-n-propyl-pyrimidine following a procedure analogous to that described for Example 15. LC (method 3): tR=0.88 min; Mass spectrum (ESI+): m/z=510 [M+H]+.

Provenance & Evidence