Triethylamine → HCID 72195115, compound

Participants

Reaction Conditions

Reaction Steps

Isobutyryl chloride (10 μL) is added to a solution of 1″-(hydroxycarbamimidoyl)-5-(1-methanesulfonyl-1,2,3,6-tetrahydro-pyridin-4-yl)-dispiro[2,3-dihydrofuro[2,3-c]pyridine-2,1′-cyclobutane-3′,4″-piperidine] (40 mg) and triethylamine (41 μL) in tetrahydrofuran (3 mL) at room temperature. The solution is stirred at room temperature for 1 h and at 45° C. overnight. The solution is diluted with methanol and concentrated. The residue is chromatographed on silica gel (cyclohexane/ethyl acetate 3:7→1:9) to give the title compound. LC (method 4): tR=1.13 min; Mass spectrum (ESI+): m/z=500 [M+H]+.

Provenance & Evidence