Ammonia → HCID 58413118, compound

HRID 240636Notes

Reaction equation

HRID 240636 reaction equation
C[O:2][C:3]([C:5]1[S:32][C:8]2[N:9]=[CH:10][N:11]=[C:12]([NH:13][C:14]3[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=3[O:21][CH:22]3[CH2:26][CH2:25][N:24]([C:27](=[O:31])[CH2:28][O:29][CH3:30])[CH2:23]3)[C:7]=2[C:6]=1[CH3:33])=O.[NH3:34]>CO>[F:20][C:17]1[CH:18]=[CH:19][C:14]([NH:13][C:12]2[C:7]3[C:6]([CH3:33])=[C:5]([C:3]([NH2:34])=[O:2])[S:32][C:8]=3[N:9]=[CH:10][N:11]=2)=[C:15]([O:21][CH:22]2[CH2:26][CH2:25][N:24]([C:27](=[O:31])[CH2:28][O:29][CH3:30])[CH2:23]2)[CH:16]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 58413011HCID 58413011, compound

Product 1

HCID 58413118HCID 58413118, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Prepared analogously to example 1.4 from 4-{4-fluoro-2-[1-(2-methoxy-acetyl)-pyrrolidin-3-yloxy]-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester and ammonia in methanol.

Sources & evidence

ORD record
ord-13f062b541254283bc416df6945e0091
Source dataset
uspto-grants-2014_02
Patent number
US08648068B2

Reaction notes

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