2-Chloro-5-(trifluoromethyl)pyrimidine → HCID 72195255, compound

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Reaction Steps

The title compound is prepared from 5-(1-methanesulfonyl-1,2,3,6-tetrahydro-pyridin-4-yl)-dispiro[2,3-dihydrofuro[2,3-c]pyridine-2,1′-cyclobutane-3′,4″-piperidine] (HCl salt) and 2-chloro-5-trifluoromethyl-pyrimidine following a procedure analogous to that described for Example 15; the reaction is conducted at 45° C. overnight. LC (method 6): tR=1.09 min; Mass spectrum (ESI+): m/z=536 [M+H]+.

Provenance & Evidence