Ammonia → HCID 58413013, compound

HRID 240637Notes

Reaction equation

HRID 240637 reaction equation
[CH3:1][N:2]([CH3:33])[CH2:3][C:4]([N:6]1[CH2:10][CH2:9][CH:8]([O:11][C:12]2[CH:17]=[C:16]([F:18])[CH:15]=[CH:14][C:13]=2[NH:19][C:20]2[C:21]3[C:28]([CH3:29])=[C:27]([C:30]([OH:32])=O)[S:26][C:22]=3[N:23]=[CH:24][N:25]=2)[CH2:7]1)=[O:5].[NH3:34]>CO>[CH3:33][N:2]([CH3:1])[CH2:3][C:4]([N:6]1[CH2:10][CH2:9][CH:8]([O:11][C:12]2[CH:17]=[C:16]([F:18])[CH:15]=[CH:14][C:13]=2[NH:19][C:20]2[C:21]3[C:28]([CH3:29])=[C:27]([C:30]([NH2:34])=[O:32])[S:26][C:22]=3[N:23]=[CH:24][N:25]=2)[CH2:7]1)=[O:5]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 58413114HCID 58413114, compound

Product 1

HCID 58413013HCID 58413013, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Prepared analogously to example 1.4 from 4-{2-[1-(2-Dimethylamino-acetyl)-pyrrolidin-3-yloxy]-4-fluoro-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid and ammonia in methanol.

Sources & evidence

ORD record
ord-b45788eb35b34b5b9276095e857bbc93
Source dataset
uspto-grants-2014_02
Patent number
US08648068B2

Reaction notes

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