Ammonia → HCID 58413213, compound

HRID 240638Notes

Reaction equation

HRID 240638 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][C@H:10]([O:13][C:14]2[CH:19]=[C:18]([F:20])[CH:17]=[CH:16][C:15]=2[NH:21][C:22]2[C:23]3[C:30]([CH3:31])=[C:29]([C:32](O)=[O:33])[S:28][C:24]=3[N:25]=[CH:26][N:27]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH3:35]>CO>[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][C@H:10]([O:13][C:14]2[CH:19]=[C:18]([F:20])[CH:17]=[CH:16][C:15]=2[NH:21][C:22]2[C:23]3[C:30]([CH3:31])=[C:29]([C:32]([NH2:35])=[O:33])[S:28][C:24]=3[N:25]=[CH:26][N:27]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 58413130HCID 58413130, compound

Product 1

HCID 58413213HCID 58413213, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Prepared analogously to example 1.4 from 4-[2-((S)-1-tert-butoxycarbonyl-pyrrolidin-3-yloxy)-4-fluoro-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid and ammonia in methanol.

Sources & evidence

ORD record
ord-ddd65f020e2a4392ae719a663a615597
Source dataset
uspto-grants-2014_02
Patent number
US08648068B2

Reaction notes

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